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Modulation of platelet thromboxane and malonaldehyde by dietary vitamin E and linoleate
Author(s) -
Hamelin Suzanne S. J.,
Chan Alvin C.
Publication year - 1983
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534560
Subject(s) - lipidology , clinical chemistry , chemistry , thromboxane , vitamin e , platelet , modulation (music) , neurochemistry , medicine , food science , endocrinology , biochemistry , psychology , antioxidant , neurology , neuroscience , philosophy , aesthetics
Thromboxane (TXB 2 ) and malonaldehyde (MDA) production by thrombin‐stimulated washed platelet were evaluated in rats fed 6 combinations of dietary vitamin E (0, 100, 1000 ppm) and linoleate (6.5 and 17.0 en%) for 23 weeks. The molar ratio of MDA:TXB 2 was consistently near 3 in all groups studied. In animals receiving the lower linoleate diets, TXB 2 and MDA synthesis were inversely related to the dietary vitamin E concentrations and the levels of MDA and TXB 2 were positively correlated (r=0.99) with decreasing vitamin E in the diet. High dietary linoleate (17.0 en%), independent of vitamin E status, reduces TXB 2 and MDA synthesis. The importance of dietary antioxidant on platelet prostanoid synthesis is discussed.