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The effect of dietary α‐linolenic acid in the rat on fatty acid profiles of immunocompetent cell populations
Author(s) -
Marshall Lisa A.,
Johnston Patricia V.
Publication year - 1983
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534542
Subject(s) - linseed oil , clinical chemistry , linoleic acid , linolenic acid , lipidology , fatty acid , polyunsaturated fatty acid , food science , biochemistry , population , alpha linolenic acid , biology , chemistry , docosahexaenoic acid , medicine , environmental health
Analysis of diet‐induced fatty acid changes in the major phospholipids of various immune cell populations has not been previously documented, particularly modifications induced by dietary α‐linolenic acid. Rats were fed purified diets containing either 10% corn oil (CO), 10% linseed oil (LO) or 10% soybean oil‐linseed mixture (SL) for 8 weeks. The α‐linolenic to linoleic acid ratios of the diets were 1∶32, 1∶1 and 3∶1, respectively. Fatty acid analysis of cell populations isolated from the spleen, thymus, thoracic cavity and peripheral blood phospholipids showed increases in ω3 fatty acids accompanied by decreases in the ω6 fatty acids when diets high in α‐linolenic to linoleic acid ratios were fed. The extent of change observed was dependent on the magnitude of the α‐linolenic to linoleic acid ratio. Both magnitude of change and the specific fatty acids altered varied with the cell population examined.