Premium
Alterations of phospholipids in ischemic canine myocardium during acute arrhythmia
Author(s) -
Man Ricky Y. K.,
Slater Tracy L.,
Pelletier Marc P.,
Choy Patrick C.
Publication year - 1983
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534533
Subject(s) - medicine , ventricle , cardiology , phospholipid , ischemia , lipidology , clinical chemistry , cholesterol , occlusion , artery , chemistry , biochemistry , membrane
Myocardial ischemia was produced in the left ventricle of the canine heart by a Harris two‐stage occlusion of the left anterior descending coronary artery. The lipid content in the ischemic myocardium was analyzed and compared with the control tissue. No significant change in total phospholipid and cholesterol was detected. A 2‐fold elevation in the levels of the major lysophospholipids was observed during acute ventricular arrhythmias at 24hr after the onset of ischemia. Such increases were not caused by preferential hydrolysis of phospholipid plasmalogens from the parent phospholipids.