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Brominated fatty acid distribution in tissues and fluids of rats fed brominated vegetable oils
Author(s) -
Lawrence James F.,
Chadha Rajinder K.,
Iverson Frank,
McGuire Peter,
Conacher Henry B. S.
Publication year - 1984
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534531
Subject(s) - chemistry , chromatography , urine , lipidology , gas chromatography , adipose tissue , gas chromatography–mass spectrometry , clinical chemistry , food science , mass spectrometry , biochemistry
Rats dosed orally for four days with 0.24 g/kg body weight per day of brominated olive oil (BOO) or brominated sesame oil (BSO) were found to accumulate dibromostearic (DBS) acid (from BOO) and DBS and tetrabromosteric (TBS) acids (from BSO) in the liver, heart and adipose tissue. The metabolites, dibromopalmitic, and dibromomyristic acids (from BOO and BSO), as well as their tetrabromo‐analogues (from BSO) were found as determined by gas chromatography with halogen specific detection and confirmed by gas chromatography‐mass spectrometry. Blood contained no DBS, TBS or metabolites. However, inorganic bromide was observed in both blood and urine while none was observed in the feces. The latter contained significant quantities of both DBS and TBS but showed the absence of the four brominated metabolites.