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Inhibition of fatty acid synthesis in isolated adipocytes by 5‐(tetradecyloxy)‐2‐furoic acid
Author(s) -
Halvorson David L.,
McCune Sylvia A.
Publication year - 1984
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534514
Subject(s) - lipidology , clinical chemistry , chemistry , fatty acid , fatty acid synthesis , biochemistry
The compound 5‐(tetradecyloxy)‐2‐furoic acid (TOFA), a hypolipidemic agent, inhibits fatty acid synthesis, lactate and pyruvate accumulation and CO 2 release in isolated at adipocytes. TOFA stimulates the accumulation of citrate. ATP levels are not lowered by TOFA. In comparison with the natural fatty acid, oleate, TOFA exhibited a much greater inhibitory effect on lipogenesis. TOFyl‐CoA formation within intact adipocytes was demonstrated. Although not inhibited by TOFA, acetyl‐CoA carboxylase is inhibited by TOFyl‐CoA. It is proposed that many of the metabolic effects of TOFA in isolated adipocytes can be explained by TOFyl‐CoA inhibition of acetyl‐CoA carboxylase. TOFA inhibits glycolysis as a secondary event with the primary event of inhibition of fatty acid synthesis causing an accumulation of citrate which is an inhibitor of phosphofructokinase.