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The influence of protein and carbohydrate type on serum and liver lipids and lipoprotein cholesterol in rabbits
Author(s) -
Bauer John E.,
Covert Steven J.
Publication year - 1984
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534513
Subject(s) - casein , cholesterol , clinical chemistry , lipoprotein , lipidology , soy protein , medicine , chemistry , endocrinology , intermediate density lipoprotein , carbohydrate , low density lipoprotein , sucrose , very low density lipoprotein , dietary sucrose , biochemistry , food science , biology
Abstract The non‐lipid portions of semi‐synthetic diets appear to be important determinants of hypercholesterolemia and atherosclerosis in the rabbit. Serum and liver lipid concentrations were determined in rabbits which had been pair‐fed various protein (casein or soy protein isolate) and carbohydrate (sucrose or dextrose) sources as part of low fat, low cholesterol, semi‐synthetic diets. It was verified that caseincontaining diets render rabbits hypercholesterolemic, while soy protein caused a degree of hypocholesterolemia. Additionally, sucrose, when fed in conjunction with casein, appears to augment this hypercholesterolemic effect. The distribution of total cholesterol among lipoprotein subclasses was increased in both the intermediate density lipoprotein (IDL) (1.006–1.019 g/ml) and low density lipoprotein (LDL) (1.019–1.063 g/ml) fractions and decreased in the high density lipoprotein (HDL) (1.063–1.21 g/ml) fraction when casein is fed. Soy protein feeding caused relatively more cholesterol to appear only in the IDL fraction when compared with commercial chow fed rabbits. Reasons for these differences may involve the saturation or suppression of endogenous lipoprotein hepatic receptors.