Premium
Alcohol ingestion and levels of hepatic fatty acid synthetase and stearoyl‐CoA desaturase activities in rats
Author(s) -
Rao G. Ananda,
Lew Gail,
Larkin Edward C.
Publication year - 1984
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534507
Subject(s) - clinical chemistry , medicine , ingestion , endocrinology , ethanol , alcohol , chemistry , lipidology , calorie , enzyme , microsome , alcoholic fatty liver , fatty acid , fatty liver , biochemistry , biology , disease
Male Sprague‐Dawley rats were fed, ad libitum for 30 days, a fat‐free (FF) liquid diet containing 34% of the calories as ethanol or a control FF diet in which alcohol was replaced by an isocaloric amount of dextrins. The cytosolic fatty acid synthetase and the microsomal stearoyl‐CoA desaturase activities in the livers of rats fed the alcohol diet were about half of those observed in the livers of control rats. The conclusion is that chronic ethanol consumption depresses the activities of these lipogenic enzymes in the liver.