Premium
Suppression of cholesterogenesis by plant constituents: Review of Wisconsin contributions to NC‐167
Author(s) -
Qureshi A. A.,
Burger W. C.,
Petterson D. M.,
Elson C.
Publication year - 1985
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534407
Subject(s) - mevalonate pathway , sterol , cholesterol , lipidology , biosynthesis , biology , clinical chemistry , biochemistry , metabolism , sterol regulatory element binding protein , enzyme
In animals, non‐sterol metabolites of the mevalonate pathway act independently from receptor‐mediated cholesterol uptake in the multivalent feedback regulation of mevalonate biosynthesis. Studies leading to the isolation and characterization of plant‐borne suppressors of mevalonate biosynthesis are reviewed. We propose that one cardio‐protective component of the vegetarian diet consists of a variety of non‐sterol, post‐mevalonate metabolites. These products of plant branches of the mevalonate pathway, discarded as animals evolved, continue to influence animal sterol metabolism. It is through this action, we propose, that the cholesterol‐suppressive action of plant materials is expressed.