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Effects of high fat diets on the activity of palmitoyl‐CoA hydrolase in rat liver
Author(s) -
Berge Rolf K.,
Thomassen Magny S.
Publication year - 1985
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534363
Subject(s) - hydrolase , rapeseed , peroxisome , clinical chemistry , lipidology , chemistry , enzyme , biochemistry , erucic acid , acyl coa , food science , gene
Palmitoyl‐CoA hydrolase [EC 3.1.2.2.] activity in rat liver was found to be enhanced by high fat diets. Partially hydrogenated marine oil and high‐erucic acid rapeseed oil diets produced a greater increase than a diet containing soybean oil. With diets containing from 5 to 30% (w/w) of partially hydrogenated marine oil the increase in palmitoyl‐CoA hydrolase activity was similar to the increase observed in peroxisomal β‐oxidation activity (correlation coefficient r=0.94). A positive correlation (r=0.86) also was observed between the activity of palmitoyl‐CoA hydrolase and previously determined levels of long‐chain acyl‐CoA. The results presented may suggest a common “induction” mechanism for palmitoyl‐CoA hydrolase and peroxisomal β‐oxidation enzymes, possibly exerted through an increased cellular level of long‐chain acyl‐CoA.

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