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Cholesteryl ester hydrolase activity in human symptomatic atherosclerosis
Author(s) -
Yatsu F. M.,
Hagemenas F. C.,
Manaugh L. C.,
Galambos T.
Publication year - 1980
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534317
Subject(s) - cholesteryl ester , clinical chemistry , peripheral blood mononuclear cell , lipidology , medicine , cholesterol , chemistry , hydrolase , endocrinology , cholesterylester transfer protein , biochemistry , lipoprotein , enzyme , in vitro
Acid cholesteryl ester hydrolase (CEH) activity was assayed in mononuclear cells of patients with symptomatic atherosclerosis (transient ischemic attacks, TIA) and in age‐matched controls showing no evidence of atherosclerosis. The acid CEH level of TIA patients was significantly lower than that of controls (1074±128 vs 2113±255 pmol/mg P/hr, mean±SE). Neither mononuclear cell nor plasma cholesterol and cholesteryl ester concentrations differed significantly between atherosclerotic and control groups. TIA women had lower mononuclear cell concentrations of free sholesterol than men.