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Oral polyunsaturated phosphatidylcholine reduces platelet lipid and cholesterol contents in healthy volunteers
Author(s) -
Galli C.,
Tremoli E.,
Giani E.,
Maderna P.,
Gianfranceschi G.,
Sirtori C. R.
Publication year - 1985
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534280
Subject(s) - chemistry , cholesterol , phospholipid , lipidology , clinical chemistry , endocrinology , platelet , medicine , thromboxane b2 , linoleic acid , phosphatidylcholine , polyunsaturated fatty acid , thromboxane , lipoprotein , high density lipoprotein , low density lipoprotein , fatty acid , biochemistry , biology , membrane
The effects of orally administered polyunsaturated phosphatidylcholine (PPC) on plasma lipids, lipoproteins and platelet function and composition were studied in seven healthy male volunteers. PPC (Nattermann & Cie, GmbH, Cologne, Federal Republic of Germany), 10 g/day, was given for a 6‐week period after a 4‐week wash out; laboratory tests were repeated after a further 4‐week period after the end of treatment. PPC did not appear, during treatment, to modify the levels of plasma total cholesterol and triglycerides. High density lipoprotein (HDL) cholesterol levels were, however, increased after six weeks of PPC. The most dramatic changes occurred in platelet membrane composition: the total lipid/total protein and the cholesterol/protein ratios were reduced significantly, whereas increases of the phospholipid/total lipid ratio and of the linoleic acid membrane content were observed. Platelet function tests, both in whole blood and in platelet rich plasma, were not modified. Similarly, the thromboxane B 2 formation after standard stimuli and the sensitivity to exogenous prostaglandin I 2 also were unchanged. During the final wash out period following treatment, a reduction of plasma total and low density lipoprotein (LDL) cholesterol levels also was recorded. PPC appears to be capable of modulating lipid exchanges between cell membranes and the plasma compartment.