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Relationship between platelet cyclooxygenase pathway and plasma malondialdehyde‐like material
Author(s) -
Violi F.,
Ghiselli A.,
Alessandri C.,
Iuliano L.,
Cordova C.,
Baslano F.
Publication year - 1985
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534266
Subject(s) - malondialdehyde , aspirin , platelet , chemistry , cyclooxygenase , ingestion , pharmacology , platelet activation , clinical chemistry , medicine , biochemistry , oxidative stress , enzyme
Thrombin‐induced platelet malondialdehyde (MDA) formation and plasma malondialdehyde‐like material (MDA‐LM) were evaluated in 12 healthy subjects before and after 1 and 7 days from aspirin (1 g) ingestion. 24 hr after aspirin administration, platelet MDA was almost abolished while MDA‐LM showed a 23% decrease. Platelet MDA and plasma MDA‐LM returned to baseline values 7 days after aspirin ingestion. These data suggest that platelet cyclooxygenase pathway affects only in part plasma MDA‐LM. The evaluation of plasma MDA‐LM before and after aspirin could be useful for evaluating in vivo platelet cyclooxygenase activation.