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Stimulation by lipoxygenase products of superoxide anion production in FMLP‐treated neutrophils
Author(s) -
Beckman Jeffrey K.,
Gay James C.,
Brash Alan R.,
Lukens John N.,
Oates John A.
Publication year - 1985
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534265
Subject(s) - superoxide , chemotaxis , chemistry , leukotriene b4 , arachidonate 5 lipoxygenase , leukotriene , arachidonic acid , lipoxygenase , stimulation , biochemistry , neutrophile , lysophosphatidylcholine , pharmacology , enzyme , in vitro , immunology , biology , phospholipid , receptor , endocrinology , phosphatidylcholine , inflammation , membrane , asthma
Our recent observation that leukotriene B 4 (10 −9 M) is a potent enhancer of FMLP‐initiated neutrophil superoxide anion formation prompted an evaluation of the ability of other lipoxygenase products and related compounds to modulate this response. The results indicate that FMLP‐evoked O 2 − may be enhanced by 10 −8 –10 −7 M levels of a number of lipids, in addition to LTB 4 , including 5‐HPETE, 5‐HETE, 5,15‐DiHPETE and by higher levels of other 15‐series lipoxygenase products and arachidonic acid. It is of interest that the relative potency of these agents in potentiating the superoxide response to FMLP approximately parallels their reported ability to induce chemotactic activity in leukocytes.