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Dietary fats containing concentrates of cis or trans octadecenoates and the patterns of polyunsaturated fatty acids of liver phosphatidylcholine and phosphatidylethanolamine
Author(s) -
Lawson Larry D.,
Hill Eldon G.,
Holman Ralph T.
Publication year - 1985
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534257
Subject(s) - polyunsaturated fatty acid , phosphatidylethanolamine , phosphatidylcholine , chemistry , linoleic acid , food science , lipidology , biochemistry , clinical chemistry , cis–trans isomerism , soybean oil , phospholipid , fatty acid , stereochemistry , membrane
The effects of the mixed cis ‐ 18∶1 isomers and mixed trans ‐18∶1 isomers present in partially hydrogenated soybean oil (PHSO) upon the patterns of polyunsaturated fatty acids (PUFA) in liver phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were studied in rats fed concentrates of cis ‐ 18∶1 or trans ‐ 18∶1 isomers isolated as triacylglycerides from PHSO. The cis ‐ 18∶1 and trans ‐ 18∶1 concentrates were fed at levels equal to those present in PHSO fed at 17.9% of the diet. All diets contained the required amounts of both linoleic and linolenic acids. The trans ‐ 18∶1 concentrate was found to suppress the levels of 20∶4ω6 and 20∶3ω9, and to increase the levels of 18∶2ω6 and 20∶5ω3 in PC and PE. The cis ‐ 18∶1 concentrate suppressed 20∶4ω6 in PC, 20∶5ω3 in PC and PE, and 18∶2ω6 was more effective than the trans concentrate in suppressing 22∶6ω3. The trans ‐ 18∶1 concentrate was more effective in suppressing 20∶4ω6. The trans ‐18∶ isomers appear to modify PUFA metabolism by inhibition of PUFA synthesis, whereas the cis ‐ 18∶1isomers appear to compete with 2‐position fatty acyl transfer and to inhibit ω3 PUFA acylation.