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Chylomicron‐like particles in severe hypertriglyceridemia
Author(s) -
Aviram Michael,
Sechter Yael,
Brook J. Gerald
Publication year - 1985
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534190
Subject(s) - chylomicron , medicine , apolipoprotein b , endocrinology , chemistry , lipoprotein , triglyceride , hypertriglyceridemia , lipoprotein lipase , cholesterol , biochemistry , very low density lipoprotein , biology , adipose tissue
Plasma lipoproteins in a diabetic patient with severe hypertrigly ceridemia and turbid, milky plasma were studied and compared with those found in three primary type V hyperlipoproteinemic and in three normal subjects after a fatty meal. All subjects had normal post‐heparin lipolytic activity. Lipoprotein electrophoresis of the patient's plasma revealed no chylomicron band, and upon short‐time ultracentrifugation the patient's supernatant showed most lipid staining in the pre‐β‐lipoprotein region. This supernatant, which in type V hyperlipoproteinemia as well as in normal subjects after a fatty meal, contains a large proportion of apolipoprotein B‐48 (of intestinal origin) was found in our patient to contain mostly apolipoprotein B‐100 (of liver origin). Upon incubation of normal washed platelets with chylomicrons derived either from type V hyperlipoproteinemic or from normal subjects after a fatty meal, platelet aggregation was decreased, whereas the chylomicron‐like particles from the patient increased platelet activity. It is, thus suggested that the triglyceride‐rich cholesterol‐poor lipoproteins are of liver and not of intestinal origin.