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Inhibition of rat hepatic sterol formation from squalene by plasma lipoproteins
Author(s) -
Srikantaiah M. V.,
Lew D. W.,
Morin R. J.
Publication year - 1980
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534178
Subject(s) - squalene , cholesterol , clinical chemistry , cytosol , intermediate density lipoprotein , sterol , lipidology , chemistry , apolipoprotein b , biochemistry , reverse cholesterol transport , microsome , cholesterylester transfer protein , apolipoprotein c2 , cholesteryl ester , lipoprotein , high density lipoprotein , squalene monooxygenase , human plasma , sterol o acyltransferase , very low density lipoprotein , in vitro , enzyme , chromatography , biosynthesis
The conversion of 3 H‐squalene to sterols by rat liver microsomes and cytosol was inhibited by individual rat and human plasma lipoproteins at various concentrations. This inhibition was also observed with added human high density apolipoprotein, but triglycerides, cholesterol or cholesteryl esters had no inhibitory effects. Lipoproteins and apo high density lipoprotein (HDL) were demonstrated to bind 3 H‐squalene in vitro. The binding of 3 H‐squalene by apo HDL could be reversed by increasing concentration of liver cytosol containing sterol carrier protein.