Identification of ergosta‐8,24(28)‐dien‐3β,6α‐diol in A Δ 8  → Δ 7  sterol isomerase‐blocked yeast mutantsterol isomerase‐blocked yeast mutant | Zendy

Pierce A. M. | Zendy; Pierce H. D. | Zendy; Unrau A. M. | Zendy; Oehlschlager A. C. | Zendy; Woods R. A. | Zendy

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Identification of ergosta‐8,24(28)‐dien‐3β,6α‐diol in A Δ 8 → Δ 7 sterol isomerase‐blocked yeast mutantsterol isomerase‐blocked yeast mutant

Author(s) -

Pierce A. M.,

Pierce H. D.,

Unrau A. M.,

Oehlschlager A. C.,

Woods R. A.

Publication year - 1979

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/bf02534132

Subject(s) - yeast , isomerase , sterol , mutant , biochemistry , ergosterol , chemistry , saccharomyces cerevisiae , stereochemistry , enzyme , gene , cholesterol

In addition to the monohydroxysterols found in the Δ 8 → Δ 7 isomerase‐blocked Saccharomyces cerevisiae mutant erg 2 , a novel dihydroxysterol, ergosta‐8,24(28)‐dien‐3β,6α‐diol, was isolated. This sterol accumulated to the extent of 2.1% of the total sterol fraction when this mutant was treated with 23‐azacholesterol, a known inhibitor of the 24‐methylene‐sterol‐24(28)‐reductase.

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