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Identification of ergosta‐8,24(28)‐dien‐3β,6α‐diol in A Δ 8 → Δ 7 sterol isomerase‐blocked yeast mutantsterol isomerase‐blocked yeast mutant
Author(s) -
Pierce A. M.,
Pierce H. D.,
Unrau A. M.,
Oehlschlager A. C.,
Woods R. A.
Publication year - 1979
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534132
Subject(s) - yeast , isomerase , sterol , mutant , biochemistry , ergosterol , chemistry , saccharomyces cerevisiae , stereochemistry , enzyme , gene , cholesterol
In addition to the monohydroxysterols found in the Δ 8 → Δ 7 isomerase‐blocked Saccharomyces cerevisiae mutant erg 2 , a novel dihydroxysterol, ergosta‐8,24(28)‐dien‐3β,6α‐diol, was isolated. This sterol accumulated to the extent of 2.1% of the total sterol fraction when this mutant was treated with 23‐azacholesterol, a known inhibitor of the 24‐methylene‐sterol‐24(28)‐reductase.