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The effect of oral contraceptives on mononuclear cell cholesteryl ester hydrolase activity
Author(s) -
Hagemenas F. C.,
Yatsu F. M.,
Manaugh L. C.
Publication year - 1980
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534116
Subject(s) - cholesteryl ester , peripheral blood mononuclear cell , progestin , estrogen , clinical chemistry , medroxyprogesterone acetate , endocrinology , medicine , lipidology , chemistry , levonorgestrel , cholesterol , population , physiology , family planning , research methodology , biochemistry , lipoprotein , in vitro , environmental health
The influence of sex steroids on mononuclear cell cholesteryl ester hydrolase (CEH) activity in premenopausal women and women on combined estrogen‐progestin oral contraceptives has been studied. In addition, plasma and mononuclear cell cholesterol and esters were measured along with plasma estrogen and progesterone levels. Mononuclear cell CEH activity in control women is highest on Day 20 of their menstrual cycle. The control women had significantly higher CEH activities than women on oral contraceptives. Plasma esters were higher in the oral contraceptive group. However, in mononuclear cells free cholesterol but not cholesteryl esters were higher in women on oral contraceptives.