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Partial synthesis of [1‐ 14 C]phytanic acid
Author(s) -
Poulos A.,
Barone E.,
Johnson D. W.
Publication year - 1980
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534112
Subject(s) - phytanic acid , nitrile , chemistry , hydrolysis , yield (engineering) , organic chemistry , iodide , sodium iodide , medicinal chemistry , nuclear chemistry , biochemistry , peroxisome , materials science , metallurgy , gene
[1‐ 14 C] Phytanic acid has been prepared in good yield from the unlabeled acid. Pristanyl iodide, prepared from the latter by a modified Hunsdieker reaction, is converted to the corresponding [ 14 C]‐nitrile by reaction with sodium [ 14 C] cyanide in dimethyl sulphoxide; hydrolysis of the [ 14 C] nitrile yields [1‐ 14 C]phytanic acid. The labeled acid should prove to be a useful substrate for the diagnosis of Refsum's disease.
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