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Distribution of phosphoinositides among subfractions of rat brain myelin
Author(s) -
Deshmukh D. S.,
Kuizon S.,
Bear W. D.,
Brockerhoff H.
Publication year - 1980
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534111
Subject(s) - phosphatidic acid , myelin , phosphatidylinositol , lipidology , pi , chemistry , biochemistry , clinical chemistry , chromatography , biophysics , biology , phospholipid , central nervous system , neuroscience , membrane , signal transduction
Rat brain myelin was separated into three subfractions, heavy, medium, and light, and the concentrations of phosphatidic acids (PA), phosphatidylinositol (PI), di‐ (DPI), and triphosphoinositide (TPI) in these fractions were determined. PI was evenly distributed among the fractions, and PA, DPI, and TPI occurred in highest concentrations in the “light” myelin. This result indicates that these fast metabolizing lipids play an important role in the tightly packed central lamellae of the myelin sheath.