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Imprints of virus infection: Can paramyxoviruses permanently modify triacylglycerol metabolism?
Author(s) -
Wild T. F.,
Bernard A.,
Malak N. Abdul,
Brichon G.,
Zwinglestein G.
Publication year - 1986
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534060
Subject(s) - lipidology , clinical chemistry , virus , lipid metabolism , metabolism , virology , biology , biochemistry , chemistry
We have examined whether the passage of a paramyxovirus in a cell (BGM, African green monkey kidney) or animal (Swiss mouse) can permanently modify its metabolism. In an in vitro model in which cells had been cured of a measles virus persistent infection, the cells retained the modifications affecting lipid metabolism and composition induced during the infection. In a canine distemper virus mouse model, the same virus‐induced modifications were observed in mice after the virus had been eliminated.