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Hepatic Δ 9 and Δ 6 desaturase activities during the recovery period following carbon tetrachloride poisoningdesaturase activities during the recovery period following carbon tetrachloride poisoning
Author(s) -
Carreau JeanPaul,
Frommel Dominique,
Nguyen Thi Thé,
Mazliak Paul
Publication year - 1980
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02534012
Subject(s) - carbon tetrachloride , microsome , chemistry , cytochrome , lipidology , biochemistry , carbon tetrachloride poisoning , ferricyanide , clinical chemistry , period (music) , kinetics , enzyme , organic chemistry , physics , quantum mechanics , acoustics
The liver microsomal Δ 9 and Δ 6 desaturase activities have been studied in rats with carbon tetrachloride‐induced hepatitis. Immediately after poisoning, significant decreases were observed for both types of desaturase activity. However, recovery kinetics were slower for the Δ 6 desaturase than for the Δ 9 desaturase. The activities of NADH‐ferricyanide and NADH‐cytochrome C reductases, proteins involved in the electron transfers associated with microsomal desaturation, were also measured. There was a fall in both activities after poisoning, but this decrease was less than that of the desaturase activities.