Premium
Arylsulfonate esters of fatty alcohols as hypocholesterolemic agents. I: Oleyl and linoleyl p‐toluenesulfonates
Author(s) -
Quackenbush Forrest W.,
Rand Phillip G.,
MacNintch John E.
Publication year - 1977
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533767
Subject(s) - chemistry , lipidology , fatty alcohol , cholesterol , fatty acid , oleyl alcohol , clinical chemistry , chromatography , organic chemistry , biochemistry , alcohol
Cholesterol levels of both plasma and liver of cholesterol‐fed rats are lowered by feeding linoleyl and oleyl esters of p‐toluenesulfonic acid. A structural specificity exists, since the effect is not observed with similar amounts of sodium p‐toluenesulfonate nor with linoleyl methanesulfonate. Effective levels of these arylsulfonates do not alter liver to body weight ratios and maturation, nor reduce plasma cholesterol in normocholesterolemic rats.