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Effect of tibric acid on hepatic cholesterol synthesis in rats
Author(s) -
Cayen M. N.,
Dubuc J.,
Dvornik D.
Publication year - 1977
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533766
Subject(s) - lipidology , clinical chemistry , cholesterol , triglyceride , chemistry , medicine , endocrinology , biochemistry , biology
Male albino rats were administered various oral doses of tibric acid daily for 1 week. Serum cholesterol and triglyceride levels were reduced, but total liver content of cholesterol, phospholipids, and triglycerides was increased. Tibric acid treatment suppressed the incorporation of both [ 14 C] acetate and [ 3 H] mevalonate into cholesterol by liver homogenates.