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Sterol‐polyene antibiotic complexation: Probe of membrane structure
Author(s) -
Bittman Robert
Publication year - 1978
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533746
Subject(s) - polyene , sterol , filipin , membrane , chemistry , antibiotics , biochemistry , phosphatidylcholine , lipidology , biological membrane , clinical chemistry , phospholipid , cholesterol
Polyene antibiotics are useful tools for studying the role of sterols in biological membranes. The interaction of polyene antibiotics with membrane‐bound sterols in artificial membrane systems, prokaryotic and eukaryotic cells, and lipid‐containing viruses is reviewed. The pentaene macrolide, filipin, is shown to serve as a probe of phosphatidylcholine‐sterol interaction and of the localization of cholesterol in the membrane of mycoplasmas.