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Arylsulfonate esters of fatty alcohols: IV. Effects on cholesterol catabolism
Author(s) -
Klauda Harry C.,
Bell Frank P.,
Grogan W. McLean,
Quackenbush Forrest W.
Publication year - 1978
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533737
Subject(s) - cholesterol , chemistry , lipidology , medicine , clinical chemistry , endocrinology , catabolism , bile acid , metabolism , biochemistry , biology
Hypercholesterolemic rats, fed 1% cholesterol and 0.5% glycocholate, were treated with arylsulfonates in various ways to observe the pattern of cholesterol elimination. Dietary linoleyl p‐toluene‐sulfonate (LTS) hastened return to normocholesterolemia and lowered hepatic cholesterol either with or without continued cholesterol feeding. LTS administered via the portal vein significantly lowered plasma cholesterol in 48 hr; ethyl linoleate and monoolein produced no lowering. LTS administered via the portal vein to glycocholate‐infused rats increased the biliary excretions of label from [4‐ 14 C]cholesterol administered intracardially and also increased total bile acid excretion 21% without increased bile volume when compared to similar injection of ethyl linoleate. No change in biliary excretion of cholesterol was seen. Bile acid kinetics were studied by using isotopic dilution techniques. Cholate turnover was enhanced by feeding oleyl p‐toluenesulfonate (OTS) and oleyl p ‐( n ‐decyl)‐benzenesulfonate (ODS) as suggested by a 16–35% decrease in half‐life in both normal and hypercholesterolemic rats. Rats consuming a grain‐based colony diet had a 54% increase in cholate synthesis when OTS was included in the diet. The composition of bile was changed when either OTS or ODS was fed; an increase in chenodeoxycholate was noted. This change was gradual with OTS but rapid with ODS and paralleled enhanced decay of chenodeoxycholate specific radioactivity in response to treatment. ODS and OTS also increased 14 CO 2 expiration from oral [26‐ 14 C] cholesterol in hypercholesterolemic rats. Dietary OTS and ODS elevated hepatic free cholesterol in hypercholesterolemic rats; ODS also elevated plasma free cholesterol and increased cholesteryl ester hydrolase activity in the liver. The data suggest that arylsulfonates stimulate cholesterol catabolism, in addition to the reported inhibition of cholesterol absorption [Lipids 12:819 (1977)].