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The terpenyl pyrophosphates of wild type and tetraterpene mutants of Neurospora crassa
Author(s) -
Kushwaha S. C.,
Kates M.,
Renaud R. L.,
Subden R. E.
Publication year - 1978
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533727
Subject(s) - phytoene , farnesyl pyrophosphate , neurospora crassa , pyrophosphate , mutant , mevalonic acid , farnesol , biochemistry , geranylgeranyl pyrophosphate , wild type , pyrophosphatases , chemistry , neurospora , stereochemistry , biology , biosynthesis , gene , prenylation , hydrolysis , enzyme
Mutations to two albino loci of Neurospora (al‐2 and al‐3 ) are known to block tetraterpene synthesis prior to phytoene but after farnesyl pyrophosphate. Analysis of the terpenyl pyrophosphates labeled with [2 14 C] mevalonic acid revealed the presence of radioactive prephytoene, pyrophosphate in both albino mutants and in the corresponding wild type strain. The al‐2 and al‐3 mutations are thus associated with lesions between prephytoene pyrophosphate and phytoene.