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1,2‐Propanediol‐induced changes in plasma and tissue lipids of rats
Author(s) -
Amma M. K. P.,
Dani H. M.,
Ahluwalia Pushpa,
Dhingra Aruna,
Kaur Jaswinder,
Kaur Charanjit,
Sharma Sushma,
Jain Kamlesh,
Singh Sarvpreet,
Sareen K.
Publication year - 1978
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533718
Subject(s) - lipidology , clinical chemistry , propanediol , chemistry , cholesterol , medicine , endocrinology , body weight , oral administration , adipose tissue , blood plasma , oral dose , biochemistry , biology , organic chemistry
Oral administration of 1,2‐propanediol to rats in a daily dose of 1 ml of 28.4% aqueous solution per 100 g body weight for 30 days caused a significant decrease in the total lipids, fatty acids, phospholipids, and triglycerides of plasma, liver, and heart, The cholesterol content in plasma decreased while that in the tissues increased significantly. The accumulation of cholesterol in tissues tends to discourage long term use of 1,2‐propanediol even by the oral route.