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Gangliosides of cultured cells of a rat mammary carcinoma cell line
Author(s) -
Keenan T. W.,
Schmid Erika,
Franke Werner W.
Publication year - 1978
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533717
Subject(s) - ganglioside , sialic acid , clinical chemistry , lipidology , mammary carcinoma , mammary gland , in vitro , cell culture , biology , biochemistry , cell , chemistry , carcinoma , membrane , cancer , genetics , breast cancer
Abstract Ganglioside content of rat mammary carcinoma‐derived cells grown in layers in vitro was nearly as high as that of apical plasma membrane‐derived milk fat globule membrane and nearly four times higher than the content of normal, lactating mammary tissue on a protein basis. The major ganglioside of these carcinoma‐derived cells was identified as GDla (sialic acid‐Gal‐GalNAc‐(sialic acid)‐Gal‐Glc‐Cer. Relative to carcinoma‐derived cells, rat mammary tissue and milk fat globule membrane had more complex ganglioside patterns but appeared to lack substantial quantities of GDla.