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Prostaglandin metabolism by human testis
Author(s) -
Carpenter M. P.,
Robinson R. D.,
Thuy L. P.
Publication year - 1978
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533678
Subject(s) - microsome , prostaglandin , clinical chemistry , endogeny , metabolism , lipidology , prostaglandin e , endocrinology , medicine , cytosol , chemistry , biosynthesis , biochemistry , biology , enzyme
Human testis preparations appear to carry out both the synthesis and turnover of prostaglandins. Prostaglandins and prostaglandin metabolites were extracted from whole tissue. Testis microsomes converted both endogenous and exogenous substrate to prostaglandins. Microsomal prostaglandin biosynthesis was inhibited by indomethacin. Prostaglandin E 2 ‐9‐ketoreductase was present in both the cytosolic and microsomal fractions of human testis. Prostaglandin metabolism by human testis has not previously been reported.