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Lipid peroxidation: A mechanism involved in acute ethanol toxicity as demonstrated by in vivo pentane production in the rat
Author(s) -
Litov Richard E.,
Irving Dennis H.,
Downey Jeanne E.,
Tappel Al L.
Publication year - 1978
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533677
Subject(s) - lipid peroxidation , vitamin e , chemistry , toxicity , pentane , ethanol , in vivo , acute toxicity , antioxidant , pharmacology , lipidology , clinical chemistry , vitamin , biochemistry , food science , medicine , biology , organic chemistry , microbiology and biotechnology
Abstract The effect of a single dose of ethanol on lipid peroxidation in three groups of rats fed different amounts of vitamin E was determined by the measurement of pentane in the breath. All rats had increased pentane production above basal levels by 15 min following oral administration of 6 g ethanol/kg body wt. The increase in total pentane production during a 13‐hr test period after intragastric administration of ethanol was greater in the rats fed the vitamin E‐deficient diet than in the rats, fed vitamin E‐supplemented diets (α=2P=0.02). The results support the hypothesis that acute ethanol toxicity involves lipid peroxidation and further demonstrate the usefulness in toxicological studies of monitoring pentane as an index of lipid peroxidation in vivo.