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The effects of certain ecdysteroids and inhibitory amines and amides on the metabolism of 22,25‐dideoxyecdysone in cockroach organ cultures
Author(s) -
Marks Edwin P.,
Robbins William E.,
Thompson Malcolm J.
Publication year - 1978
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533666
Subject(s) - cockroach , ecdysone , moulting , metabolism , hormone , inhibitory postsynaptic potential , chemistry , biochemistry , insect , biology , endocrinology , medicine , larva , botany , ecology
Abstract An organ culture assay system using cockroach leg regenerates and fat body has been developed in which compounds that either inhibit molting hormone metabolism or act as molting hormone antagonists can be tested. Representatives of three classes of compounds were tested in the system: ecdysteroids, azasteroids, and nonsteroidal amines and amides. Inhibitory compounds were found in all three of the classes. Certain of these inhibitors represent a new class of insect hormonal compounds with a novel mode of action—the disruption of molting hormone metabolism.