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Stimulation of hepatic lipogenesis by eicosa‐5,8,11,14‐tetraynoic acid in mice fed a high linoleate diet
Author(s) -
Abraham S.,
McGrath Hope,
Ananda Rao G.
Publication year - 1977
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533631
Subject(s) - lipidology , lipogenesis , clinical chemistry , stimulation , medicine , endocrinology , chemistry , lipid metabolism , biology
Liver slices, from mice fasted for one day and then refed for three days either a 15% corn oil diet or a 15% corn oil diet containing eicosa‐5,8,11,14‐tetraynoic acid (TYA), were incubated with [1‐ 14 C] acetate or [ 3 H]H 2 O to determine lipogenic capacity. Dietary TYA produced a twofold stimulation in fatty acid and cholesterol synthesis. TYA also caused an increase in the relative proportion of linoleate (C 18∶2 ) and a decrease in that of arachidonate (C 20∶4 ) in liver. Thus, (a) despite high levels of C 18∶2 , hepatic lipogenesis can be increased, and (b) even short term feeding of TYA can alter the hepatic fatty acid composition presumably by inhibition of arachidonate synthesis from linoleate.