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High and low density lipoprotein cholesterol levels in hypercholesterolemic school children
Author(s) -
Morrison John A.,
Groot Ido,
Kelly Kathe A.,
Edwards Brenda K.,
Mellies Margot J.,
Tillett Sandra,
Khoury Phillip,
Glueck Charles J.
Publication year - 1979
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533577
Subject(s) - percentile , cholesterol , medicine , lipidology , endocrinology , clinical chemistry , high density lipoprotein , coronary heart disease , lipoprotein , statistics , mathematics
Abstract To most fully explicate risk to coronary heart disease (CHD) in adults and children with elevated plasma total cholesterol, the levels of high and low density lipoprotein cholesterol (C‐HDL, C‐LDL) must be quantitated. This report focuses upon C‐HDL and C‐LDL levels in children identified in a lipid and lipoprotein sampling survey of 6,775 Princeton School children, by either total plasma cholesterol ≥205 mg/dl, the approximate 95th percentile for children 6–17 years of age, or age‐, sex‐, and race‐specific 95th percentiles for cholesterol. Using the sex‐, race‐specific local 95th percentiles for C‐HDL and C‐LDL, the hypercholesterolemic children were separated into four categories according to whether they had elevations of both C‐HDL and C‐LDL, C‐HDL only, C‐LDL only, or neither. When selection for hypercholesterolemia was based on the overall 95th percentile (205 mg/dl), black children were more likely than white to have elevations of C‐HDL only, which accounted for their hypercholesterolemia, p<.05, whereas white children were much more likely to have elevations of C‐LDL only, than were black children, p<.005. However, when selection for hypercholesterolemia was based on age‐, sex‐, and race‐specific 95th percentile cholesterol levels, there were no differences in the proportion of black and white children having elevations of C‐HDL and C‐LDL, accounting for their hypercholesterolemia. Elevated levels of C‐HDL can explain apparent hypercholesterolemia in at least 16% of children, ages 6–17, who may putatively be at reduced, rather than increased CHD risk.