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The importance of the steric configuration of lysophosphatidylcholine in the lymphatic transport of fat
Author(s) -
O'doherty P. J. A.
Publication year - 1979
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533574
Subject(s) - lysophosphatidylcholine , phosphocholine , clinical chemistry , steric effects , chemistry , lipidology , biochemistry , lymphatic system , enantiomer , medicine , stereochemistry , phosphatidylcholine , phospholipid , membrane , pathology
The importance of the steric configuration of lysophosphatidylcholine in the lymphatic transport of fat was investigated in bile fistula rats. It was found that the feeding of 1‐palmitoyl‐ sn ‐glycero‐3‐phosphocholine increased the lymphatic output of phosphatidyl choline and triacylglycerol, while the feeding of 3‐palmitoyl‐ sn ‐glycero‐1‐phosphocholine had no effect. In intestinal microsomes of the bile fistula rats, it was found that the lysophosphatidylcholine acyltransferase was stereospecific in acylating the 1‐acyl‐ sn ‐glycero‐3‐phosphocholine enantiomer. The significance of these findings is briefly discussed.