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Effect of oxidized oil on lipogenic enzymes
Author(s) -
Iritani Nobuko,
Fukuda Eiko,
Kitamura Yohko
Publication year - 1980
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533553
Subject(s) - malic enzyme , corn oil , chemistry , food science , lipogenesis , enzyme , lipidology , cod liver oil , biochemistry , triglyceride , thiobarbituric acid , soybean oil , dehydrogenase , clinical chemistry , metabolism , cholesterol , lipid peroxidation
Male Wistar rats were fed for 4 wk on diets containing 2% oxidized corn oil. Liver tissue was then studied to determine the effect of feeding peroxidized oil on lipogenic enzymes. Although substances which reacted with thiobarbituric acid increased in liver microsomes and mitochondria with increasing peroxide values of the dietary corn oil fed, the activities of glucose‐6‐phosphate dehydrogenase, malic enzyme and acetyl‐CoA carboxylase in liver were unchanged. However, when rats were fed for 2 wk on diets containing 10% fat, of which 0.5, 5 or 10% was unoxidized corn oil and the remainder was hydrogenated beef tallow filler, the lipogenic enzyme activities and also the liver triglyceride levels were observed to decrease with increasing amounts of dietary corn oil. Therefore, although a synthetic diet containing corn oil was easy to oxidize spontaneously, the reductions of lipogenic enzymes in rats fed the diet would not have been caused by lipid peroxides but by unsaturated fatty acids themselves.