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Lipid composition of morris hepatoma 5123c, and of livers and blood plasma from host and normal rats
Author(s) -
Ruggieri S.,
Fallani A.
Publication year - 1979
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533516
Subject(s) - chemistry , palmitic acid , stearic acid , phosphatidylinositol , arachidonic acid , oleic acid , cholesteryl ester , clinical chemistry , endocrinology , phosphatidylcholine , medicine , biochemistry , lipidology , cholesterol , fatty acid , phospholipid , biology , organic chemistry , enzyme , lipoprotein , signal transduction , membrane
The lipid composition of Morris hepatoma 5123c was analyzed together with that of liver and blood plasma from both normal and tumor‐bearing rats. The results showed that the liver of tumor‐bearing rats contained higher amounts of glycerides, cholesteryl esters, free fatty acids and phospholipids than the liver of normal rats. In the blood plasma of tumor‐bearing rats, there was an increase of free cholesterol and triglycerides; this latter difference, however, was not statistically significant. Acyl chain changes in the liver of tumor‐bearing rats consisted of an increase of palmitic and oleic acids and a decrease of stearic and arachidonic acids in phosphatidylinositol. Morris hepatoma 5123c contained a lower amount of triglycerides than the livers (both host and normal) and showed a significant decrease of total phospholipids when compared to the host liver. The major acyl chain changes found in Morris hepatoma 5123c compared with both normal and host rat livers were: a) a higher percentage of arachidonic acid together with a lower proportion of palmitic acid in cholesteryl esters; b) an increase of stearic and arachidonic acids and a decrease of palmitic acid in triglycerides; and c) a higher level of palmitic and oleic acids associated with a lower percentage of stearic and C 22 polyunsaturated acids in phosphatidylcholine.