Premium
Effect of serum lipoproteins of bile obstructed rats on 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase activity in perfused rat liver
Author(s) -
Barak A. J.,
Sorrell M. F.,
Tuma D. J.
Publication year - 1979
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533500
Subject(s) - lipidology , clinical chemistry , coenzyme a , reductase , chemistry , medicine , endocrinology , hydroxymethylglutaryl coa reductase , biochemistry , enzyme , hmg coa reductase
Total lipoproteins as well as fractionated VLDL+LDL and HDL from fasted control rats and bileligated rats were tested in liver perfusion for their effect on 3‐hydroxy‐3‐methylglutaryl CoA reductase to increase 3‐hydroxy‐3‐methylglutaryl CoA reductase activity than that of the control total lipoproteins. When the fractionated lipoproteins were tested from fasted control rats, it was found that the major stimulating activity was in the HDL fraction with minor activity in the VLDL+LDL fraction. When these plasma components isolated from fasted bile‐ligated rats were tested, it was found that the major activity had shifted to the VLDL+LDL fraction with the HDL having only a minor stimulatory role. The possible mechanism of action of the abnormal lipoproteins associated with bile obstruction in regulating 3‐hydroxy‐3‐methylglutaryl CoA reductase activity is discussed.