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The incorporation of orally administered radiolabeled dihomo γ‐linolenic acid (20∶3ω6) into rat tissue lipids and its conversion to arachidonic acid
Author(s) -
Hassam A. G.,
Crawford M. A.
Publication year - 1978
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533479
Subject(s) - arachidonic acid , clinical chemistry , chemistry , linolenic acid , lipidology , biochemistry , fatty acid , metabolism , oral administration , pharmacology , linoleic acid , biology , enzyme
Radioactivity from orally administered radiolabeled dihomo‐γ‐linolenic acid (20∶3ω6) was recovered from the liver, plasma and brain lipid fractions. After administration the fatty acid was metabolized to arachidonic acid, the 22 carbon chain length fatty acid, and was also β‐oxidized. However, 22 hr after administration of [1‐ 14 C]20∶3 between one‐third and one‐half of the recovered radioactivity was still associated with dihomo‐γ‐linolenic acid in the liver and plasma lipid fractions. Orally administered dihomo‐γ‐linolenic acid is incorporated into lipid fractions and is, therefore, available in the metabolic pool for PGE 1 synthesis.