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Desaturation of eicosa‐11,14‐dienoic acid in human testes
Author(s) -
Albert D. H.,
Rhamy R. K.,
Coniglio J. G.
Publication year - 1979
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533468
Subject(s) - lipidology , clinical chemistry , arachidonic acid , microsome , biochemistry , chemistry , metabolism , enzyme , medicine
The metabolism of [1‐ 14 C]eicosa‐11,14‐dienoic acid was investigated in human testes using whole tissue minces and microsomal preparations. Both types of preparations catalyzed the desaturation of the labeled diene to eicosa‐8,11,14‐trienoic as well as eicosa‐5,11,14‐trienoic acid. The reported results, therefore, indicate that human testicular tissue, as well as rat testicular tissue (reported previously), is capable of utilizing eicosa‐11,14‐dienoic acid as a precursor of arachidonic acid. Since it is known that there is no Δ 8 desaturase activity in rat liver and brain, these studies support the concept that there is a tissue variation in this enzymatic pathway.