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Epoxides as products of lipid autoxidation in rat lungs
Author(s) -
Sevanian Alex,
Mead James F.,
Stein Robert A.
Publication year - 1979
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533449
Subject(s) - autoxidation , epoxide , chemistry , oxidizing agent , lipidology , biochemistry , organic chemistry , clinical chemistry , lipid peroxidation , fatty acid , food science , catalysis , antioxidant
The nature and content of lipid epoxides in rat lung were examined in air‐breathing control rats and those exposed to nitrogen dioxide. Exposure to 6.5 ppm NO 2 for 24 hr resulted in significantly greater epoxide content in a number of lipid classes. It is proposed that lipid autoxidation in lung tissues may contribute to the levels of epoxide‐containing lipids. Furthermore, the processes involved in epoxide formation may be predicted from autoxidation studies utilizing a system of unsaturated fatty acid monolayers on silica gel which serves as a model for biomembranes. The findings indicate that exposure to oxidizing gases can lead to an accumulation of lipid epoxides in both lung parenchymal tissue and on the alveolar surface.