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Kidney lipids: Changes caused by dietary 9‐ Trans , 12‐ Trans ‐octadecadienoate
Author(s) -
Kinsella J. E.,
Yu P. H.,
Mai J. B.
Publication year - 1979
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533442
Subject(s) - chemistry , linoleic acid , arachidonic acid , kidney , food science , cis–trans isomerism , fatty acid , medicine , endocrinology , biochemistry , biology , organic chemistry , enzyme
Trans, trans ‐linoleate at 50 and 100% of dietary fat decreased kidney size and altered its composition. Trans, trans ‐linoleate as the sole source of dietary fat imparied growth and caused more severe symptoms of essential fatty acid deficiency than was observed with hydrogenated coconut oil (HCO). The concentration of renal cholesterol, phospholipids (PL), triglycerides (TG) and cholesteryl esters (CE) were also decreased. Linoleic (18∶2), homo‐γ‐linolenic acid (20∶3n6) and arachidonic acid (20∶4n6) were significantly depressed in lipid classes, especially in PL and CE, by dietary trans, trans ‐linoleate. The increase in eicosatrienoate (20∶3n9), especially in PL and CE of kidneys of rats fed HCO (essential fatty acid deficient), was slight in rats fed 100% trans, trans ‐linoleate, indicating that the trans, trans acid probably inhibited acyl elongation and desaturation.