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Changes in the cholesterol and phospholipid content of mouse spleen after Rauscher Leukemia Virus infection
Author(s) -
Montfoort A.,
Boere W. A. M.,
Van Griensven L. J. L. D.
Publication year - 1976
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533406
Subject(s) - spleen , sphingomyelin , phospholipid , lipidology , cholesterol , leukemia , clinical chemistry , choline , biology , friend virus , virus , chemistry , biochemistry , murine leukemia virus , virology , membrane , immunology
The effect of Rauscher Leukemia Virus (MuLV‐R) infection on the lipid composition of mouse spleen from BALB/c mice was investigated. Drastic changes in the lipid composition of the spleen as a result of tumor growth induced by the virus could be demonstrated at 21 days after infection. The molar ratio of cholesterol to phospholipids was found to be low, while a shift within the choline containing phospholipid classes resulted into a lower sphingomyelin and a higher phosphatidyl choline content of the MuLV‐R infected spleen. The cholesterol ester content increased more than two‐fold during tumor growth, and shifts in the fatty acid patterns of the lipids were demonstrated.