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Levels of cyclic 3′‐5′‐adenosine monophosphate (cAMP) in maintenance cultures of rat hepatocytes in response to insulin and glucagon
Author(s) -
Geelen Math J. H.,
Vaartjes Willem J.,
Gibson David M.
Publication year - 1977
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533384
Subject(s) - glucagon , insulin , lipidology , adenosine , medicine , cyclic adenosine monophosphate , clinical chemistry , endocrinology , chemistry , insulin response , biochemistry , biology , plasma glucose , receptor
Under conditions of short‐term stimulation of lipogenesis by insulin in maintenance cultures of hepatocytes from starved rats, basal levels of cyclic 3′‐5′‐adenosine monophosphate (cAMP) are invariant. Glucagon signals increased levels of cAMP and severely diminishes lipogenesis. Insulin partially counteracts both glucagon effects.