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Synthesis of a monobrominated analog of dipalmitoyl lecithin
Author(s) -
Reinert J. C.,
Lowry R. R.,
Wickman H. H.
Publication year - 1978
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533371
Subject(s) - lecithin , chemistry , chromatography , thin layer chromatography , lipidology , fatty acid , conjugated system , organic chemistry , stearic acid , polymer
The synthesis of 1‐palmitoyl‐2‐monobromopalmitoyl lecithin, where the β‐chain is brominated in either the 9‐ or 10‐position, is reported, Monobromopalmitic acid was prepared by addition of HBr to palmitoleic acid, and the anhydride of the fatty acid conjugated with 1‐palmitoyl lysolecithin. The resulting lecithin was isolated by preparative thin layer chromatography and its structure confirmed by chemical and enzymatic analysis.