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Composition and synthesis of three higher ganglioside homologs in bovine mammary tissue
Author(s) -
Bushway Alfred A.,
Keenan T. W.
Publication year - 1978
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533368
Subject(s) - ceramide , ganglioside , sialic acid , galactose , biochemistry , mammary gland , chemistry , sphingolipid , golgi apparatus , fatty acid , glycolipid , biology , cell , apoptosis , cancer , breast cancer , genetics
Three higher gangliosides were identified as constituents of bovine mammary gland. The structures of these three gangliosides were shown to be ceramide‐glucose‐galactose‐(sialic acid)‐N‐acetylgalactosamine‐galactose, ceramide‐glucose‐galactose‐(sialic acid) 2 ‐N‐acetylgalactosamine, and ceramide‐glucose‐galactose‐(sialic acid) 2 ‐N‐acetylgalactosamine‐galactose These gangliosides accounted for only a small fraction (<20%) of the lipid‐bound sialic acid in mammary gland. While fatty acids with even carbon numbers from C 14 to C 26 were predominant in these gangliosides, they also contained C 23 and C 25 fatty acids. Mammary gland Golgi apparatus‐rich fractions had all glycosyltransferases required for synthesis of these gangliosides starting with ceramide.