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Tissue lipid responses to 3‐hydroxy‐3‐methylglutaric acid with different dietary fats
Author(s) -
Yousufzai S. Y. K.,
Siddiqi Majid
Publication year - 1977
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533343
Subject(s) - lipidology , clinical chemistry , chemistry , food science , biochemistry , lipid metabolism , medicine , endocrinology , biology
Simultaneous administration of 3‐hydroxy‐3‐methylglutaric acid (HMG) for 4 weeks to rats fed 20% saturated fats prevented rise of serum cholesterol, triglycerides, and phospholipids. Except phospholipids, other liver lipids were significantly decreased. HMG administration for 4 weeks along with atherogenic diet significantly decreased cholesterol and phospholipids of serum, liver, aorta, and heart. The phospholipids of epididymal fat and brain were also significantly lowered. The triglyceride levels in serum, liver, and epididymal fat were significantly decreased. The maximal hypolipidemic effect of HMG was observed in serum.