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Ether‐linked glycerolipids in human brain tumors
Author(s) -
Albert Daniel H.,
Anderson Carl E.
Publication year - 1977
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533292
Subject(s) - oligodendroglioma , human brain , lipidology , meningioma , astrocytoma , chemistry , clinical chemistry , plasmalogen , choline , ether , brain tumor , biochemistry , phospholipid , biology , pathology , glioma , medicine , cancer research , organic chemistry , neuroscience , membrane
In this investigation, the lipid composition of a number of human brain tumors was determined and compared to that of normal adult brain. Glioblastomas (11 samples), astrocytomas (4 samples), an acoustic neurinoma, an oligodendroglioma, and a meningioma were analyzed. All of the tumors had substantial levels (0.8–3.4% of total phospholipids) of choline plasmalogen which was present in only trace amounts in normal brain. With the exception of the acoustic neurinoma and the meningioma, the concentration of alkylacylglycerophosphorylcholine was also higher in the tumors than in normal brain. Neutral lipids of brain tumors also contained high concentrations of both alkyl (1.6–4.8% of total neutral glycerolipids) and alkenyl diacyl glycerol (3.8–10.1%). The results from this investigation indicate that increases in etherlinked glycerolipids may be characteristic of human brain tumors.