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Chain length specificity in the utilization of long chain alcohols for ether lipid biosynthesis in rat brain
Author(s) -
Natarajan V.,
Schmid H. H. O.
Publication year - 1977
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533279
Subject(s) - chemistry , ethanolamine , alcohol , fatty alcohol , alkyl , ether , glycerol , biosynthesis , oleic acid , lipidology , biochemistry , clinical chemistry , fatty acid , phospholipid , choline , organic chemistry , enzyme , membrane
A mixture of cis ‐9‐[1‐ 14 C] octadecenol and [1‐ 14 C] docosanol was injected into the brains of 19‐day‐old rats, and incorporation of radioactivity into brain lipids was determined after 3, 12, and 24 hr. Both alcohols were metabolized by the brain but at different rates; each was oxidized to the corresponding fatty acid, but oleic acid was more radily incorporated into polar lipids. Substantial amounts of radioactivity were incorporated into 18∶1 alkyl and alk‐1‐enyl moieties of the ethanolamine phosphoglycerides and into 18∶1 alkyl moieties of the choline phosphoglycerides. Even after the disappearance of the 18∶1 alcohol from the substrate mixture (12 hr), the 22∶0 alcohol was not used to any measurable extent for alkyl and alk‐1‐enyl glycerol formation.