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Effects of parathion on lipolysis in isolated rat adipose tissue cells
Author(s) -
Caley Richard M.,
Jensen Robert G.
Publication year - 1973
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/bf02533238
Subject(s) - lipolysis , parathion , medicine , endocrinology , chemistry , adipose tissue , lipase , nicotinamide , white adipose tissue , biochemistry , biology , enzyme , pesticide , agronomy
The effects of the pesticide, Parathion (0,0‐diethyl 0‐ p ‐nitrophenyl thiophosphate) and various lipolytic and antilipolytic agents on lipolysis in adipose tissue were studied with isolated fat cells from rat epididymal fat pads. Lipolysis was measured as the release of free fatty acids into an albumin‐bicarbonate medium. Parathion depressed lipolysis in a linear manner at concentrations ranging from 10 −9 to 10 −3 M. At a concentration of 10 −5 M, Parathion depressed the lipolytic response to epinephrine (0.15 μg/ml) and slightly to cyclic 3′,5′‐adenosine monophosphate (10 −3 M) and enhanced the antilipolytic response to nicotinic acid (33 μM). It is possible that Parathion may interfere with adenyl cyclase activity.